Islet Neogenesis Associated Protein-related Protein: from Gene to Folded Protein

نویسندگان

  • Michael D. Kulis
  • Suzanne B. Shuker
  • Nael McCarty
چکیده

iii ACKNOWLEDGEMENTS God, I thank you for giving me the ability and determination to become a scientist. You could have taken me so many times, and for that I'm convinced I'm here for a real reason. Robin, I can't thank you enough for helping to turn my mind to the Most High. To my family, I love you ALL!! Mom and Grama, without you I would be nowhere. Dad, I'm glad I decided to forgive you…I love you. Chris and Kelly, what can I say, just keep doing your thing, you will find your treasures in due time. Amber, I'm just glad we met. We went through so much together, it's amazing we're still close. I will always be here for you…anything you need I will do my best to provide. Because of you I know what unconditional love is. As for everyone at IBB: Suzy, thanks for taking a chance on me. It's been hard at times, but I'm a better person for going through graduate school. To my committee, thanks for having faith in me. You all could have kicked me out after that first candidacy exam, but you saw some potential in me. I don't think I've fully realized the potential and when I do it's going to be a sight to behold. Vicki, you were a great teacher, both in and out of the lab. Thanks for " understanding Sketchy ". Bryan, thanks for all the help with the molecular biology and NMR. Best of luck in all you pursue. KJ, what can I say, I'll never forget the day you took me to the health center after I ate the banana walnut bagel, when I could barely breathe. Remember how swollen my face was? Damn, it still scares me just thinking about that. Josh and Beth, thanks for the entertainment. Dr. Gelbaum, thanks for putting up with me and all my failed NMR experiments. I think we both had faith that it would eventually work though. Charlie, iv thanks for all your advice and especially for the help with my FPLC work. Foster, you're like a brother, sometimes I love ya, sometimes I wanna kill you. Thompson, it's great knowing you, even though UCLA hoops will always have the edge on Kentucky. Thanks for letting me live with you and all, I won't soon forget about you.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The role of islet neogeneis-associated protein (INGAP) in pancreatic islet neogenesis.

Efforts to cure diabetes are now focused on restoring a physiologically-regulated population of insulin-producing cells to the patient. A number of animal models of beta cell regeneration have been employed to study the mechanisms of the process. Islet neogenesis, the regeneration of pancreatic islets from pancreatic stem cells, is arguably the least fraught with barriers to widespread use as a...

متن کامل

Molecular cloning and tissue-specific expression of a new member of the regenerating protein family, islet neogenesis-associated protein-related protein.

Islet neogenesis-associated protein (INGAP) is a protein expressed during islet neogenesis. We have cloned a novel cDNA having a similar sequence to INGAP cDNA. The cDNA encodes 175 amino acids designated INGAP-related protein (INGAPrP). INGAP is expressed in cellophane-wrapped pancreas, but not in normal pancreas, whereas INGAPrP was abundantly expressed in normal pancreas.

متن کامل

Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters.

Induction of islet neogenesis by cellophane wrapping (CW) reverses streptozotocin-induced (STZ) diabetes. Administration of Ilotropin, a protein extract isolated from CW pancreata, causes recapitulation of normal islet ontogeny and reverses STZ diabetes, reducing mortality by 50%. We investigated the hypothesis that a novel gene encoding a constituent of Ilotropin was expressed in the hamster p...

متن کامل

Prospects and challenges for islet regeneration as a treatment for diabetes: a review of islet neogenesis associated protein.

Diabetes mellitus results from inadequate insulin action, which can be viewed as a consequence of the limited ability to restore beta cells after they are lost as the result of metabolic exhaustion, autoimmune destruction, or surgical insult. Arguably, a uniformly effective therapeutic pathway to address all forms of diabetes would be to reverse the restrictions on beta-cell and islet regenerat...

متن کامل

Immunohistochemical characterization of pancreatic duodenal homeobox protein-1, neurogenin-3 and insulin protein expressions in islet-mesenchymal cell in vitro interactions from injured adult pancreatic tissues: a morphochronological evaluation

Objective(s): The use of a co-culture of islets with mesenchymal stromal cells (MSCs) is a promising therapy in islet transplantation to revert hyperglycaemia, but the resulting insulin-producing cells (IPCs) express low levels of pancreas endocrine developmental genes. This study aims to investigate the morphochronology of a co-culture of islets with MSCs from injured adult pancreata, and char...

متن کامل

Identification and prioritization genes related to Hypercholesterolemia QTLs using gene ontology and protein interaction networks

Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. Familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. Hypercholesterolemia is a quantitativ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2006